Conference Agenda

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Session Overview
Session
IP08: Jeremy Gunawardena: Some mathematical aspects of gene regulation
Time:
Friday, 12/Jul/2019:
1:30pm - 2:30pm

Location: vonRoll, Fabrikstr. 6, 001
468 seats, 433 m^2

Presentations
1:30pm - 2:30pm

Some mathematical aspects of gene regulation

Jeremy Gunawardena

Harvard Medical School, United States of America

The “linear framework” describes biochemical systems under timescale separation in terms of a finite directed graph with labelled edges. When applied to gene regulation, the framework gives a gene's input-output response as a rational function of the graph labels. The sharpness of the response, or the sensitivity of output to changes in inputs, is important for understanding how gene-regulatory mechanisms control the the development of the organism during ontogeny as well as how such mechanisms evolve during phylogeny. We outline some mathematical problems relating to the sharpness of genetic input-output responses, with a focus on the role of energy expenditure away from thermodynamic equilibrium.